19-08-2014, 12:10 PM
A 3D pharmacophore of the test molecules was developed by selecting the most active molecules belonging to major classes of RSV inhibitors using the available software. The developed pharmacophore hypothesis was validated by a set of 100 molecules belonging to the class of benzimidazole-2-one. This was then utilized to generate a 3D QSAR study using the available software modules.
A 3D pharmacophore of the test molecules was developed by selecting the most active molecules belonging to major classes of RSV inhibitors using the available software. The developed pharmacophore hypothesis was validated by a set of 100 molecules belonging to the class of benzimidazole-2-one. This was then utilized to generate a 3D QSAR study using the available software modules.