21-09-2013, 03:46 PM
EFFECT OF DIFFERENT VISCOSITY GRADES OF ETHYL CELLULOSE ON EXTENDED RELEASE PROPERTIES OF POTASSIUM CHLORIDE TABLETS
EFFECT OF DIFFERENT VISCOSITY.pptx (Size: 98.04 KB / Downloads: 32)
Extended release formulation
The goal of using extended release formulations is to maintain an effective therapeutic concentration of the drug for an extended period of time. Especially drugs with a short half life are good for this formulation. The rate of drug release equal to rate of drug eliminated thus ensures that the drug concentration is within the therapeutic window for about 24hrs. Rate of drug diffused is influenced by the matrix pores and wet ability of the formulation. API having long half life (over 6hrs) sustained on its own.
Aim & Objective
Aim is to formulate extended release formulation of highly water soluble drug (potassium chloride) by using different viscosity grade of ethyl cellulose as a rate controlling polymer and also to study the effect of different viscosity grades of ethyl cellulose on extended release properties of potassium chloride.
Method of preparation:
Three film coated solutions were prepared separately by dissolving required quantity of ethyl cellulose (600mg, 900mg, 1200mg) in 20ml of isopropyl alcohol by continuous stirring, required quantity of KCl weighed and previously passed through sieve 16# and is added to film coating solutions with constant stirring and are concentrated.
Granules are dried at 60˚C for 2hrs and then all coated granules are incorporated in HPMC K4 100 mucilage with vigorous stirring ( to prevent initial burst effect) and dried .The dried granules passed through sieve 16# . Fines are separated and 1% fines are added and blended with remaining excipients and compressed in multi station tablet punching machine. Finally tablets are coated with 1% EC with respective viscosity grades (control the initial release of drug from tablet). Evaluation tests are carried out. As KCl exists in ionic form, it is analyzed by using Flame emission spectroscopy.
Conclusion
Based on dissolution study we conclude that F1 showed better result because initial release of KCl is important for first 2hrs and followed USP release pattern .Polymer coating is mainly responsible for initial release and also extended release of drug from tablet.