20-12-2012, 06:47 PM
Anatomy and Physiology of Dental Pulp
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Functions of dental pulp
Formation of dentine (dentinogenesis)
Sensation (pain only?)
First line of defense to injuries and infection of dentine
Tertiary dentine
Immuno-competent
Clearance of toxic substances
Components of dental pulp
CELLS (odontoblast, fibroblast, undifferentiated cell, macrophage, dendritic cell)
FIBERS AND GLYCOPROTEIN (collagen type I, III, no elastic fiber, fibronectin)
GROUND SUBSTANCES (glycosaminoglycans, chondroitin sulfate proteoglycan)
BLOOD VESSELS, NERVES, LYMPH VESSELS
Functions of pulpal extracellular matrix
Maintain tissue’s physical properties and integrity
Control of growth and development and repairs
Control of cell migration
Control of diffusion of macromolecules
Collagen in dental pulp
Concentration varies from species to species, 32% in human pulp.
Higher content in the middle and apical pulp.
Total collagen decreases with age.
Interestingly high level of collagen type III. (43%) : vascular content, tissue extensibility (cf. Elastin)
Absence of elastin (except in b.v.).
Adhesive glycoproteins in dental pulp
Fibronectin found in predentine NOT mature dentine.
Fibronectin present in pulp and dental papilla.
Fibroblasts synthesize pulpal fibronectin.
Fibronectin is expressed during reparative dentinogenesis.
Glycosaminoglycans in dental pulp
Chondroitin sulfate, dermatan sulfate, hyaluronic acid present
Amount of uronic acid decreases with age
Total GAG decreases with reduced dentinogenic activity
Decorin may involve in mineral nucleation at the mineralization front