19-08-2014, 12:09 PM
The molecules designed were docked into the RecA receptor crystal structure using the available computer software. Synthesis of a few candidates which showed moderate to good results was carried out.
The molecules designed were docked into the RecA receptor crystal structure using the available computer software. Synthesis of a few candidates which showed moderate to good results was carried out.
A series of NCE's (new chemical entities) were synthesized to obtain nitrogen containing cyclic as well as acyclic molecules. The common starting material for synthesis of all the candidates was aminoguanidine hydrochloride.