27-09-2014, 12:10 PM
DEVLOPMENT AND IN VITRO EVALUATION OF
GASTRORETENTIVE FLOATING TABLETS OF FAMOTIDINE
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Abstract
The present study reports the development and in vitro evaluation of gastro retentive floating tablets of
Famotidine. The formulations were developed using cellulose derivatives such as HPMC K4M, HPMC K15M and
HPMC K100M in different ratios with gas generating agents and other excipients by wet granulation
technique. The formulations were subjected to various evaluation parameters in vitro, viz., hardness, friability,
uniformity of drug content, in vitro floating studies, in vitro dissolution studies, All the formulations were good in
appearance and showed better physical and mechanical properties. Formulation M15 containing HPMC K4M
80 mg, Sodium bicarbonate 40 mg, 30 mg citric acid and PVP K30 10mg was found to be the best
formulation in terms of drug release and in vitro buoyancy time and was subjected to stability studies and IR
spectroscopy .The results indicate that the formulation was stable and there was no chemical interaction
between the polymer and the drug.
Introduction
Gastric emptying is a complex process and is highly
variable and results in uncertain absorption of drugs
this can be overcome by a proper drug delivery
system such as gastro retentive drug delivery system.
The GRDDS can be used to retain the drug in the
stomach thereby increasing the absorption and
bioavailability of the drug. This system is particularly
important for the drugs which have higher absorption
rate in a particular region of gastrointestinal tract1.
Famotidine is a potent H2 receptor antagonist used in
the treatment of peptic ulcer, reflex eosophagitis etc. It
is absorbed mainly at a specific absorption site in the
GIT. A dosage form which can retain Famotidine at its
absorption site for an extended period will increase its
absorption and bioavailability
Evaluation of Gastro Retentive Floating Tablets of
Famotidine
The prepared gastro retentive tablets were evaluated
for hardness (Monsantotester), friability (Rochetype
friabilator), weight variation4,5, drug content estimation,
floating lag time and total floating time.
In vitro Buoyancy Studies
In- vitro buoyancy studies were performed for all the
eight formulations as per the method described by
Rosa et al6 Randomly selected tablets from each
formulation were introduced in a 100ml beaker
containing simulated gastric fluid, PH 1.2 as per USP.
The time taken for the tablet to rise to the surface and
float was taken as floating lag time (FLT). The time for
which the dosage form constantly remained on the
surface of medium was determined as the total floating
time (TFT).The results were depicted in Table.No-2
Conclusion
From the results of the study it is evident that the gastro
retentive floating tablets of Famotidine can be
successfully developed by using cellulose derivatives in
combination with gas generating agents and this would
be a feasible alternative to conventional oral dosage
form of Famotidine in order to retain the drug at the