19-08-2014, 12:11 PM
Emergence of multi-drug resistant strains of pathogenic organisms has caused rapid rise in the incidence of microbial infections. There is a need to develop selective target oriented drugs with high potency.
Emergence of multi-drug resistant strains of pathogenic organisms has caused rapid rise in the incidence of microbial infections. There is a need to develop selective target oriented drugs with high potency.
Taking pyrimidinone ring as the starting moiety, a series of molecules were designed and synthesized which showed moderate to good results when docked to the RecA crystal structure. Synthesis of pyrimidinone derivatives were also tried out using multicomponent reactions. The synthesized molecules were characterized by IR, H1 NMR, C13 NMR and MS and tested for anti-microbial activity.