25-08-2017, 09:32 PM
Fast dissolving tablets
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Definition
Fast Dissolving Tablets (FDTs) or “mouth dissolving tablets” (MDTs) which disintegrates or dissolves rapidly without water within few seconds in the mouth.
significance
It offer all advantages of solid dosage forms and liquid dosage forms along with special advantages, includes
It provide good stability, accurate dosing, easy manufacturing, small packaging size & easy to handle.
No need of water to swallow the dosage form.
Easy to administer for paediatric, geriatric & institutionalized patients.
More rapid drug absorption from the pre-gastric area which may produce Quick onset of action.
Pre-gastric absorption of drug avoids hepatic metabolism, which reduces the dose and increase the bioavailability.
The risk of chocking or suffocation during oral administration avoided.
Good mouth feel property of MDDDS helps to change the basic view of medication as "bitter pill"
Patient’s compliance for disabled bedridden patients and for travelling and busy people, who do not have ready access to water.
Requirements of ODTs
Dissolve / disintegrate in the mouth in matter of seconds without water.
Have sufficient mechanical strength and good package design.
Not affected by drug properties.
Effective taste masking technologies should be adopted for bitter taste drugs.
Leave minimal or no residue in mouth after oral administration.
Exhibit low sensitivity to environment condition such as humidity and temperature