26-08-2016, 01:51 PM
1444547450-microbivores.rtf (Size: 2.39 KB / Downloads: 7)
Nanomedicine offers the prospect of powerful new tools for the treatment of human diseases and the improvement of human biological systems using molecular nanotechnology. This paper presents a theoretical nanorobot scaling study for artificial mechanical phagocytes of microscopic size, called "microbivores" whose primary function is to destroy microbiological pathogens found in the human bloodstream using a digest and discharge protocol. The microbivore is an oblate spheroidal nanomedical device measuring 3.4 microns in diameter along its major axis and 2.0 microns in diameter along its minor axis, consisting of 610 billion precisely arranged structural atoms in a gross geometric volume of 12.1 micron. It is an ideal nanotechnology-based drug delivery system which is—self-powered, computer-controlled medical nanorobot system capable of digitally precise transport, timing, and targeted delivery of pharmaceutical agents to specific cellular and intracellular destinations within the human body. Microbivores will have many applications in nanomedicine such as initiation of apoptosis in cancer cells and direct control of cell signaling process
What would an ideal drug delivery vehicle look like? To start with, it would be targetable not just to specific tissues or organs, but to individual cellular addresses within a tissue or organ. Alternatively, it would be targetable to all individual cells within a given tissue or organ that possessed a particular characteristic (e.g., all cancer cells, or all bacterial cells of a definite species, etc.). This ideal vehicle would be biocompatible and virtually 100% reliable, with all drug molecules being delivered only to the desired target cells and none being delivered elsewhere so that unwanted side effects are eliminated. The ideal vehicle would remain under the continuous control of the supervising physician, including post-administration. Even after the vehicles had been injected into the body, the doctor would still be able to activate or inactivate them remotely, or alter their mode of action or operational parameters. Once treatment was completed, all of the vehicles could be removed intact from the body, leaving no trace of their presence