19-08-2014, 12:29 PM
Microemulsion based (2%) spray formulation of Mupirocin containing O, N Carboxymethyl chitosan- Zinc complex was prepared. The formulation was optimized with the help of ternary phase diagrams.
Microemulsion based (2%) spray formulation of Mupirocin containing O, N Carboxymethyl chitosan- Zinc complex was prepared. The formulation was optimized with the help of ternary phase diagrams.
Formulated spray was evaluated for pH, drug content of formulation and per actuation of spray, body surface area covered by spray, particle size and polydispersity index determination, determination of zeta potential, specific gravity, viscosity, effect of freeze thaw cycling, antimicrobial activity, primary skin irritation studies. Developed formulation exhibited better antimicrobial activity than marketed formulation.
The formulation has shown no signs of skin irritation and it is stable for 3 month under accelerated stability conditions as per ICH guidelines.