25-10-2012, 10:59 AM
PIAS Proteins in Androgen Signaling nd Prostate Cancer
ABSTRACT
It has been well established that androgen receptor (AR) plays an important role in prostate cancer. Previous studies have
suggested that the PIAS (protein inhibitor of activated STAT) family may be involved in the regulation of AR-mediated gene
activation. The overall goal of this proposal is to study the role of PIAS proteins in androgen signaling and prostate tumor
progression.