19-08-2014, 11:50 AM
The design of experiments (DOE) and response surface methodology (RSM) studies are carried out for the optimization of reaction parameters.
Lactol is a key intermediate in the synthesis of various drugs such as antimalarial drugs, prostaglandin analogues, steroid receptor modulators and 1, 3-dioxane alkenoic acids. A number of limitations such as long reaction times, excess use of reducing agents and low yields were observed with the reported processes for reduction of lactone to lactol. Therefore, a new process has been developed for the eduction of lactone to lactol using modified reducing agent.
The design of experiments (DOE) and response surface methodology (RSM) studies are carried out for the optimization of reaction parameters.