19-08-2014, 11:53 AM
Development of Gastro Retentive Dosage form of Diltiazem Hydrochloride using ion exchange resin.
Development of Gastro Retentive Dosage form of Diltiazem Hydrochloride using ion exchange resin.
Rapid gastrointestinal transit could result in incomplete drug release from the device above the absorption zone leading to diminished efficacy of the administered dose. Retention of drug delivery system in the stomach prolongs overall Gastro intestinal transit time and improves the oral bioavailability of drug that are having site-specific absorption from the stomach or upper parts of the small intestine. Recently ion exchange resin has shown potential in extended release formulations as a release retarding agent.
They were incorporated into hydroxypropylmethylcellulose (HPMC) matrix tablets to modify the release of oppositely charged drugs. A physical mixture of drug, resin and HPMC was blended to make the tablets. Diltiazem hydrochloride was chosen as a drug the present study. It has an elimination half life of 3.5 hours as well as relatively stable over a pH of 3-6. Extended release gastro retentive dosage forms of Diltiazem hydrochloride were prepared using different grades of strong cation exchange resins and cellulose polymers. Drug, Ion Exchange resin, polymer and other exipients were geometrically mixed and compressed into tablets using Direct Compression method. From the present study it was found that the combination of Methocel® K100M CR and Natrosol along with Ion Exchange Resin able to control the release and match with the specification.
Odor masking and formulation development of choline bitartrate. Choline is an essential nutrient frequently referred as vitamin B4 that is widely distributed in foods, principally in the form of phosphatidylcholine but also as free choline. It is an essential nutrient for all age groups. Choline is commercially available as different salts as choline dihydrogen citrate, choline chloride and choline bitartrate. Choline bitartrate is most commercially used in pharmaceutical industries however; Choline bitartrate is very hygroscopic and has a fishy odor leading to user non compliance. The study was focused on stabilization of Choline Bitartrate with respect to its hygroscopicity and fishy odor and this stabilized product incorporate in user friendly dosage form. The experiments were carried out using carnauba wax in combination with castor oil, sesame oil in order to increase the coating efficiency. This coated choline bitartrate was incorporated in user friendly mouth dissolving granules. The developed formulations were evaluated for taste, mouth feel, in-vitro dispersion time, assay, flow properties, effervescence and release studies.
The product was found to be stable.