Microwave irradiation and biocatalysis are important and rapidly developing technologies in green and sustainable engineering. The synergistic effect of microwave irradiation and lipase catalysis on transesterification of ethyl (2E) -3-phenylprop-2-enoate and 4,8-dimethylnon-7-en-1-ol was studied using immobilized enzymes such as such as Novozym 435, Lipase AYS amino, Lipozyme RMIM and Lipozyme TL IM. Novozym 435 was the best catalyst among those studied. The effects of various parameters affecting conversion and initial transesterification rates were studied to establish kinetics and mechanism. There is synergism between enzymatic catalysis and microwave irradiation, an increase in initial rates of up to 2.3 times in microwave irradiation than in conventional heating was observed. With a substrate concentration of 0.03333 kmol / m 3 of ethyl (2E) -3-phenylprop-2-enoate and 0.06667 kmol / m 3 of 4,8-dimethylnon-7-en-1-ol in n- heptane, Novozym 435 gave a conversion of 94% to 333 K in 21600 s. Analysis of the initial velocity and progress curve data showed that the reaction obeys the ternary complex ordered bi-bi mechanism with inhibition by 4,8-dimethylnon-7-en-1-ol. The theoretical predictions and the experimental data agree very well.