19-08-2014, 12:02 PM
The development of antimicrobial agents to treat infections has been one of the most notable medical achievements of the past century. These advances in medical care are threatened, however, by a natural phenomenon known as "antimicrobial resistance".
The development of antimicrobial agents to treat infections has been one of the most notable medical achievements of the past century. These advances in medical care are threatened, however, by a natural phenomenon known as "antimicrobial resistance".
Biosynthesis of bacterial cell wall components has long been accepted as a target for antibiotic action.
Crucially most bacteria require meso-diaminopimelic acid (DAP) as a component of the peptidoglycan layer of the cell wall. Since mammals do not make or use DAP, inhibitors of the DAP biosynthetic pathway would not be expected to show mammalian toxicity. DAP was thus selected as a target for development of new antibacterial agents.
Novel Agents as structural analogues of DAP were synthesized. 1,3 thiazole-2-thiol was substituted in the molecules as it shows promising antibacterial activity. The synthesized molecules were purified by recrystallization and column chromatography and characterized by IR and NMR spectroscopy. These were then subjected to bacterial testing in order to evaluate their antimicrobial activity.