Waste generated by industries causes environmental problems. Therefore, the reuse of this waste material can be emphasized. Marble Dust Powder (MDP) is a composite material in development that will allow the industry to optimize the use of the material, generate economic benefits and build structures that are strong, durable and sensitive to the environment. MDP is a by-product obtained during the quarrying process from the parent marble rock; which contains a high content of calcium oxide of more than 50%. The potential use of MDP may be an ideal option to replace in a cement binder as it increases the reactivity efficiency due to the presence of lime. In this research work, the MDP of waste passing through 90 microns, has been used for the investigation of hardened concrete properties. In addition, the effect of different percentages of MDP substitution on the compressive strength, fracture breaking strength (indirect tensile strength) and flexural strength have been observed. In this experimental study, the effect of MDP on resistance is presented. Five concrete mixtures containing 0%, 5%, 10% and 20% of MDP have been prepared as a substitution of cement based on weight. The water / cement ratio (0.43) remained constant in all concrete mixtures. The compressive strength, breaking fracture strength and flexural strength of concrete mixtures were obtained at 7 and 28 days. The results of the laboratory work showed that the cement replacement with MDP increases, up to 10% for the compressive strength and up to 15% for the tensile strength and flexural strength of the concrete.