Now one day the concept of controlled release is quiet popular among formulation scientists. The aim of this study was to develop a once-daily Nimesulide sustained release tablet using hydroxylpropylmethylcellulose (HPMC K4M) as a release control factor and to evaluate the drug release parameters according to various kinetic release models. The tablets were prepared using a wet granulation method. Five lots were prepared, of which two selected batches were further evaluated. Different dissolution models were applied to the drug release data in order to evaluate release mechanisms and kinetics. The "n" value of both batches indicates that the drug release mechanism follows the "anomalous transport". From all of these data it is fairly clear that lot F2 is optimized since its release kinetics was found to be according to the Korsmeyer Peppas model rather than the first order of F4.