15-10-2014, 03:56 PM
Activation of the sperm motility and chemotatic behavior of sperm towards egg is the first communication between spermatozoa and egg in the events leading to fertilization. The nature of molecules derived from eggs by which sperm are activated and attracted to the eggs and the molecular mechanism underlying the sperm activation and chemotaxis have been investigated in only a few invertebrate species, sea urchins, ascidians and herring fish where fertilization is external. However, knowledge on this phenomenon has been ignored in mammalian species including humans. Therefore an understanding of the phenomenon is a prerequisite for progress of not only basic biology, but also clinical aspects. We hope to get valuable information from this project concerning the molecules to which sperm would respond. Identification of these molecules could open up new vistas in the development of reproductive healthcare products particularly in the areas of diagnostics and therapeutics of fertility related issues.
Outlay: 13.96 Lakhs