25-09-2014, 01:24 PM
Abstracts: In this project the use of subcritical carbon dioxide is illustrated to precipitate ultrafine solid particles. The process has been developed to attain rapid, high,and uniform supersaturation by drastic reduction of the solution temperatureand is named PPRGEL (precipitation by pressure reduction of gas-expanded liquids). Rapid pressure reduction over a CO(2)-expanded liquid solution from 40-70 to 1 bar at 303 K reduces the solution temperature by 30-80 K in a very short span of time (0.5-1.5 min) and facilitates precipitation of ultrafine particles. The process performance has been evaluated for particle production of 3 Active Pharmaceutical Ingredients namely Curcumin, Fenofibrate and Griseofulvin from 100 mL of their acetone solutions(5-10 mg/mL) at 40-70 bar and 303 K using a 1 L high-pressure vessel. Particles with a size range of 200 nm to 7 um have been produced with a change in operating conditions.