07-05-2012, 03:22 PM
Biomaterial Classifications – Lecture Slide Set 7
[attachment=21481]
Learning Objectives 7:
Hydrogel polymers
Swelling behavior
Smart polymers
Temperature induced transitions
Solvent induced transitions
Drug delivery platform
LCST Behavior – Smart Polymers
Synthesis of heterobifunctional mPEG-lys- block -PNIPAm-biotin block copolymers (left) and schematic representation of the association of mPEG-Lys- block -PNIPAm-biotin copolymers in response to temperature (right), with PNIPAm chains collapsing into a micellar core (black central aggregate) as the temperature increases above the LCST, thus hiding the biotin ligands in the center of the aggregate. 2 mPEG indicates poly(ethyleneglycol)-methyl ether; PNIPAm, poly (N-isopropylacrylamide); LCST, lower critical solution temperature; DMP, 2- Dodecylsulfanylthiocarbonylsulfanyl-2-methyl propionic acid; RAFT, Radical Addition Fragmentation Transfer; BMCC, 1-biotinamido-4-[4 ′ -(maleimidomethyl) cyclohexanecarboxamido]butan
Polyplex smart molecules
Schematic representation of the 3-layered polyplex micelle made up of ABC triblock copolymers lac-PEG-PSAO-PAMA and DNA (left). The 3 protonation states of PSAO are shown (right), moving from unprotonated PSAO, which is insoluble in water in a globule state (top), to fully protonated PSAO (bottom), which is soluble in water and has a rigid structure with rotation about ethylene bonds restricted by interactions of nitrogen and silicon with protons and chloride ions, respectively. 5 Lac-PEG-PSAO-PAMA indicates lactosylated PEG- block -polysilamine- block -poly[2-(N,N- dimethylamino)ethyl methacrylate;
Additional References
Macromolecules, An Introduction to Polymer Science, F. A. Bovey, F.H. Winslow, ed, Academic Press (1979) ISBN 0-121-19755-7
Fundamental Principles of Polymeric Materials, 2nd Edition, Stephen L. Rosen, Wiley Interscience (1993) ISBN 0-471-57525-9
Polymer Science and Technology, Joel R. Fried, Prentice Hall PTR (1995) ISBN
[attachment=21481]
Learning Objectives 7:
Hydrogel polymers
Swelling behavior
Smart polymers
Temperature induced transitions
Solvent induced transitions
Drug delivery platform
LCST Behavior – Smart Polymers
Synthesis of heterobifunctional mPEG-lys- block -PNIPAm-biotin block copolymers (left) and schematic representation of the association of mPEG-Lys- block -PNIPAm-biotin copolymers in response to temperature (right), with PNIPAm chains collapsing into a micellar core (black central aggregate) as the temperature increases above the LCST, thus hiding the biotin ligands in the center of the aggregate. 2 mPEG indicates poly(ethyleneglycol)-methyl ether; PNIPAm, poly (N-isopropylacrylamide); LCST, lower critical solution temperature; DMP, 2- Dodecylsulfanylthiocarbonylsulfanyl-2-methyl propionic acid; RAFT, Radical Addition Fragmentation Transfer; BMCC, 1-biotinamido-4-[4 ′ -(maleimidomethyl) cyclohexanecarboxamido]butan
Polyplex smart molecules
Schematic representation of the 3-layered polyplex micelle made up of ABC triblock copolymers lac-PEG-PSAO-PAMA and DNA (left). The 3 protonation states of PSAO are shown (right), moving from unprotonated PSAO, which is insoluble in water in a globule state (top), to fully protonated PSAO (bottom), which is soluble in water and has a rigid structure with rotation about ethylene bonds restricted by interactions of nitrogen and silicon with protons and chloride ions, respectively. 5 Lac-PEG-PSAO-PAMA indicates lactosylated PEG- block -polysilamine- block -poly[2-(N,N- dimethylamino)ethyl methacrylate;
Additional References
Macromolecules, An Introduction to Polymer Science, F. A. Bovey, F.H. Winslow, ed, Academic Press (1979) ISBN 0-121-19755-7
Fundamental Principles of Polymeric Materials, 2nd Edition, Stephen L. Rosen, Wiley Interscience (1993) ISBN 0-471-57525-9
Polymer Science and Technology, Joel R. Fried, Prentice Hall PTR (1995) ISBN