30-01-2013, 03:36 PM
FORMULATION AND CHARACTERIZATION OF MICROSPHERE OF CONTROLLED RELEASE DRUG DELIVERY SYSTEMS OF GLIMEPRIDE LOADED MICROSPHERE USING BIODEGRADABLE POLYMER
[attachment=48935]
PROPOSED PROTOCOL
FORMULATION AND CHARACTERIZATION OF MICROSPHERE OF CONTROLLED RELEASE DRUG DELIVERY SYSTEMS OF GLIMEPRIDE LOADED MICROSPHERE USING BIODEGRADABLE POLYMER
Introduction:
Controlled drug delivery technology represents one of the frontier areas of science, which involves multidisciplinary scientific approach, contributing to human health care. These delivery systems offer numerous advantages compared to conventional dosage forms, which include improved efficacy, reduced toxicity, and improved patient compliance and convenience. Such systems often use macromolecules as carriers for the drugs. By doing so, treatments that would not otherwise be possible are now in conventional use. This field of pharmaceutical technology has grown and diversified rapidly in recent years. Among the different dosage forms reported, microspheres and microparticles have gained much importance.
Literature survey:
1. Mucoadhesive microsphere of oral anti diabetic drug¬-Glipizide using different polymer.
Der Pharmacia Lettre, 2011, 3(2): 496-506 A. Senthil, T. Sivakumar, V.B. Narayanaswamy
2. In vitro evaluation of novel sustained release microspheres of glipizide prepared by the emulsion solvent diffusion-evaporation method by P Phutane, S Shidhaye,
3. Multiunit Floating Drug Delivery System of Rosiglitazone Maleate: Development, Characterization, Statistical Optimization of Drug Release and In Vivo Evaluation by Madan Mohan Kamila, Nita Mondal, Lakshmi Kanta Ghosh, and Bijan Kumar Gupta AAPS PharmSciTech, Vol. 10, No. 3, September 2009
After through search of literature it was found that few antidiabetic drugs such as Rosiglitazone Maleate & Glipizide have been developed into suitable microspheric drug delivery system with excellent results to fulfill its purpose, but till now no microsphere drug delivery system of Glimepride has been developed for controlled release of drug to extended period of time in view of above it was planned to devlop microspheric drug delivery system of Glimepiride by using suitable biodegradable polymer with an aim to provide better control release profile & increased therapeutic efficacy.
Objective:
The objective of the current investigation is to reduce dosing frequency and improve patient compliance by designing and systematically evaluating sustained release microspheres of Glimepiride. An anti-diabetic drug, is delivered through the microparticulate system using controlled release biodegredable polymer. Microsphere can be designed to allow controlled drug release from the matrix. These properties of microsphere enable improvement of drug bioavailability and reduction of the dosing frequency, and may resolve the problem of non adherence to prescribed therapy. Microsphere for the purpose of drug delivery are defined as submicron (< 100µm) colloidal particles.
Methodology:
1. Procurement of bulk drug.
2. Preformulation studies,
a. Calibration curve
b. Validation of analytical process: precision, specificity, range, linearity.
3. Identification of polymer.
4. Procurement and characterization of polymer.
Procedure:
Methods available for preparation of microspheres
1. Emulsification & solvent evaporation technique.
2. Polymerization technique.
3. Phase separation coacervation technique.
4. Spray drying.
5. Solvent extraction.
[attachment=48935]
PROPOSED PROTOCOL
FORMULATION AND CHARACTERIZATION OF MICROSPHERE OF CONTROLLED RELEASE DRUG DELIVERY SYSTEMS OF GLIMEPRIDE LOADED MICROSPHERE USING BIODEGRADABLE POLYMER
Introduction:
Controlled drug delivery technology represents one of the frontier areas of science, which involves multidisciplinary scientific approach, contributing to human health care. These delivery systems offer numerous advantages compared to conventional dosage forms, which include improved efficacy, reduced toxicity, and improved patient compliance and convenience. Such systems often use macromolecules as carriers for the drugs. By doing so, treatments that would not otherwise be possible are now in conventional use. This field of pharmaceutical technology has grown and diversified rapidly in recent years. Among the different dosage forms reported, microspheres and microparticles have gained much importance.
Literature survey:
1. Mucoadhesive microsphere of oral anti diabetic drug¬-Glipizide using different polymer.
Der Pharmacia Lettre, 2011, 3(2): 496-506 A. Senthil, T. Sivakumar, V.B. Narayanaswamy
2. In vitro evaluation of novel sustained release microspheres of glipizide prepared by the emulsion solvent diffusion-evaporation method by P Phutane, S Shidhaye,
3. Multiunit Floating Drug Delivery System of Rosiglitazone Maleate: Development, Characterization, Statistical Optimization of Drug Release and In Vivo Evaluation by Madan Mohan Kamila, Nita Mondal, Lakshmi Kanta Ghosh, and Bijan Kumar Gupta AAPS PharmSciTech, Vol. 10, No. 3, September 2009
After through search of literature it was found that few antidiabetic drugs such as Rosiglitazone Maleate & Glipizide have been developed into suitable microspheric drug delivery system with excellent results to fulfill its purpose, but till now no microsphere drug delivery system of Glimepride has been developed for controlled release of drug to extended period of time in view of above it was planned to devlop microspheric drug delivery system of Glimepiride by using suitable biodegradable polymer with an aim to provide better control release profile & increased therapeutic efficacy.
Objective:
The objective of the current investigation is to reduce dosing frequency and improve patient compliance by designing and systematically evaluating sustained release microspheres of Glimepiride. An anti-diabetic drug, is delivered through the microparticulate system using controlled release biodegredable polymer. Microsphere can be designed to allow controlled drug release from the matrix. These properties of microsphere enable improvement of drug bioavailability and reduction of the dosing frequency, and may resolve the problem of non adherence to prescribed therapy. Microsphere for the purpose of drug delivery are defined as submicron (< 100µm) colloidal particles.
Methodology:
1. Procurement of bulk drug.
2. Preformulation studies,
a. Calibration curve
b. Validation of analytical process: precision, specificity, range, linearity.
3. Identification of polymer.
4. Procurement and characterization of polymer.
Procedure:
Methods available for preparation of microspheres
1. Emulsification & solvent evaporation technique.
2. Polymerization technique.
3. Phase separation coacervation technique.
4. Spray drying.
5. Solvent extraction.