01-06-2013, 04:18 PM
SOLUBILITY
[attachment=54645]
INTRODUCTION:
PROPERTY OF A SOLID, LIQUID OR GAS TO DISSOLVE IN SOLID, LIQUID OR GAS.
IN QUANTITATIVE TERM
IN QUALITATIVE TARM
EXPRESSION OF SOLUBILITY:-
ACCORDING TO USP AS NUMBER OF MILILETRES OF SOLVENT IN WHICH 1 GRAM OF SOLUTE WILL DISSOLVE
HILDEBRAND& SCOTT APPROACH:-
SOLVENT POWER OF A LIQUID IS INFLUENCED BY ITS INTERMOLECULAR COHESIVE FORCES & THAT THE STRENGTH OF THESE FORCES.
CO-SOLVANCY:
solubilisation of drug into co-solvent
weak electrolyte and non nonpolar molecules have poor water solubility can be improve by altering
polarity of solvents.
Solubility enhancement as high as 500 fold achieved using 20% 2-pyrollidone.
HYDROTROPHY:
it increase the solubility in water due to presence of large amount of additives.
eg. sodium benzoate, urea.
[attachment=54645]
INTRODUCTION:
PROPERTY OF A SOLID, LIQUID OR GAS TO DISSOLVE IN SOLID, LIQUID OR GAS.
IN QUANTITATIVE TERM
IN QUALITATIVE TARM
EXPRESSION OF SOLUBILITY:-
ACCORDING TO USP AS NUMBER OF MILILETRES OF SOLVENT IN WHICH 1 GRAM OF SOLUTE WILL DISSOLVE
HILDEBRAND& SCOTT APPROACH:-
SOLVENT POWER OF A LIQUID IS INFLUENCED BY ITS INTERMOLECULAR COHESIVE FORCES & THAT THE STRENGTH OF THESE FORCES.
CO-SOLVANCY:
solubilisation of drug into co-solvent
weak electrolyte and non nonpolar molecules have poor water solubility can be improve by altering
polarity of solvents.
Solubility enhancement as high as 500 fold achieved using 20% 2-pyrollidone.
HYDROTROPHY:
it increase the solubility in water due to presence of large amount of additives.
eg. sodium benzoate, urea.