02-06-2012, 11:38 AM
AIDS ACQUIRED IMMUNO- DEFICIENCY SYNDROME SLIM DISEASE
AIDS.ppt (Size: 546.5 KB / Downloads: 214)
AGENT FACTOR
1st called as “ lymphadenopathy - associated virus” LAV by French scientist
Human T- cell lympho tropic virus III(HTLV-III)
may 1986 international committee of taxonamy named it as HIV
Source of infection
in greatest concentration in blood, semen &CSF
lower concentration in tear, saliva , breast milk, urine , & cervical and vaginal secretion
brain tissue, lymph node bone marrow& skin
HOST FACTOR
Age : 20-50 yrs childbearing & child rearing age
Children make 3% of total cases
Sex: 70% homosexual &bisexual male
Certain sexual Practise increases the risk- multiple sexual partner , annual inter course, male homosexuality higher rate in prostitute
High risk group: Homosexuals, Bisexuals, Hetro sexual , Prostitutes, I.V drug abusers, Transfusion recipients of blood, &blood product, Hemophiliac,
IMMUNOLOGY
The CD4+ cells play a key role in regulating the immune response
HIV virus depletes it
Also infects B-cells microphages and nerve cells
On replication it destructs the T-helper cells
WBC
ratio of t-helpers to t suppressors cells may be an indirect indicator of cell immunity