28-12-2012, 05:34 PM
Total Sensing/Analysis Systems
Total Sensing.pdf (Size: 1.72 MB / Downloads: 302)
Arrays, Single Cells, and Single Molecules
Performing lots of experiments
Looking for rare events
Single Cells
Dynamics of intercellular calcium oscillation
Exhibit wide range of responses. Understanding
how individual cells respond may lead to understanding of
how exposure leads to disease. May also enable toxicity
Challenges and Opportunities
• Target Identification—What to measure? Match
available sensor capabilities to needs. Surrogates?
• Sample Collection—number of samples, representative
samples, Poisson sampling
• Sample type—alternative sample matrices (e.g. saliva)
• Improve sensor sensitivity
• Expand analyte suite
• Data Processing and Integration
• Ancillary sensor issues—Power, Deployment
strategies (e.g. cell phones,robots, air currents)
• System Integration
Conclusions
• Important to specify target analytes.
Surrogates should be considered.
• Some sensors are available in that can be
used for monitoring.
• Where monitoring cannot be performed,
sample collection is a good alternative.
• For many measurement needs for exposure
assessment, laboratory based instruments
should be employed.