15-09-2017, 02:47 PM
Rapidly disintegrating tablets (FDTs) have received increasing demand over the last decade, and the field has become a rapidly growing area in the pharmaceutical industry. Oral administration of drugs remains the preferred route of administration of various drugs. Recent developments in technology have led scientists to develop FDTs with better patient compliance and convenience. Upon introduction into the mouth, these tablets dissolve or disintegrate in the mouth in the absence of additional water for the easy administration of active pharmaceutical ingredients. The popularity and usefulness of the formulation resulted in the development of several FDT technologies. FDTs are solid unit dosage forms, which disintegrate or dissolve rapidly in the mouth without chewing and water. FDTs or oral disintegrating tablets provide an advantage particularly for pediatric and geriatric populations having difficulty swallowing conventional tablets and capsules. This review describes various formulations and technologies developed to achieve rapid dissolution / dispersion of tablets in the oral cavity. In particular, this review describes in detail FDT technologies based on lyophilisation, molding, sublimation and compaction, as well as approaches for improving FDT properties, such as spray drying and the use of disintegrants.