17-08-2012, 02:42 PM
Formulation and Evaluation of Antimicrobial Activity of Medicated Jelly with Ajowan Extract
Formulation and Evaluation of Antimicrobial Activity.pdf (Size: 43.82 KB / Downloads: 54)
Introduction:
Jellies are transparent, opaque, nongreasy
semisolid gels generally applied externally. They
are used for medication, lubrication and some
miscellaneous application. gelling agent used
normally are tragacanth, sodium alginate,pectin,
starch, gelatin, cellouse derivative like HPMC,
SCMC, MC, carbomer,pvp(1).
Preparations containing gelling agent that
merges or entangles to form a three- dimensional
colloidal network structure. Medicated jellies are
chiefly used on mucus membrane and skin for their
spermicidal, local anesthetic and antiseptic
properties (2).Skin injuries, local infections and
tissue cleansing can be best treated by application
of product that form transparent water vapour and
air permeable film over the skin surface from
which the drug releases continuously from the
application site.
Evaluation of formulated jellies:
Prepared Ajowan extract jellies were evaluated
for appearance, pH, spreadibility, stability and
antimicrobial activity. All the formulations were
visually inspected for clarity, colour, homogeneity,
presence of particles and fibers.
Appearance:
The Ajowan extract jellies having sodium
alginate was opaque in appearance whereas with
tragacanth it was milky white transparent in
appearance.
Determination of pH:
The pH values (Table 2) of 1% aqueous
solutions of the prepared jellies were checked by
using a calibrated digital pH meter (Elico India) at
constant temperature.
Spreadability (5):
For the determination of spredability excess of
sample was applied in between two glass slides and
was compressed to uniform thickness by placing
1000 gm weight for 5 minutes. The time required
to separate the two slides i.e., the time in which
upper glass slide moves over the lower plate was
taken as measure of spredability(S)(6).
Conclusion
Medicated jelly with ajowan extract was
formulated using sodium alginate. Jelly with
sodium alginate shows good physiochemical
properties.The antimicrobial activity of this gel
formulation is comparable to standard.
The result suggests the feasibilility of medicated
jelly for hand sensitizer. However preclinical
studies of this formulation need to be done.