23-08-2013, 02:39 PM
A SEMINAR ON PER FORMULATION STUDIES OF BIOTECHNOLOGICAL PRODUCTS
FORMULATION STUDIES.ppt (Size: 2.1 MB / Downloads: 51)
INTRODUCTION
Product of interaction between BIOLOGY & TECHNOLOGY
Applied science-basic science incorporate in it like microbiology, physiology, physics etc…
Various branches like genetic & process engineering,enzyme , hybridoma & Fermentation technology,
CLASSES OF DRUGS
Anti-Coagulants/Anti-thrombolytic
Erythropoeitins to treat anaemia
Interferons to treat cancer
Monoclonal antibodies – Cancer
Interleukins-Cancer Immunotherapy
Vaccines-Hepatitis B,AIDS,Cancer
Endogenous peptide –CHF & Auto-immune disease
TECHNIQUE
Cloned peptides & proteins.
Conjugation of proteins & peptides
Conjugation of peptides & proteins to various polymer
Eg.Dextran,Poly vinyl pyrrolidone,poly ethylene glycol,albumin
Increase in half-life,decrease immunogenicity,increase in water solubility.
INTERPRETATION THROUGH CASE STUDIES:
Pharmaceutical and immunological evaluation of human papillomavirus virus like particles as an antigen carrier
Preformulation and formulation development of Anthrax vaccine powder for nasal mucosal delivery
Effect of pH and ionic strength on the physical stability
Thermal stability of Adenovirus type 2 as a function of pH
Biotechnological drugs official in IP’96
Hepatitis B virus vaccine
Hyaluronidase inj.
Insulin
Japanese encephalitis vaccine
Rabies vaccine
Human rabies vaccine (neural tissue)
Diphtheria, tetanus and pertusis vaccine (adsorbed)
Tetanus vaccine (adsorbed)
Human albumin solution
Cholera vaccine