04-07-2013, 04:18 PM
USE OF NATURAL PLANT BASED EXCIPIENT AS A BINDER IN THE FORMULATION DEVELOPMENT OF PHARMACEUTICAL SOLID ORAL UNIT DOSAGE FORM
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Abstract
Natural gums are economic, easily available and found useful as tablet binder. The present study is done to evaluate the gum of mangifera indica (mango) as tablet binder employing paracetamol as model drug.(1) The physicochemical properties of a gum obtained from the stem of Mangifera indica(MIG) were characterized viz. Elemental analysis, Fourier transmittance infra red, Thermo gravimetric analysis(TGA), Scanning electron microscopy (SEM) and X-ray powder diffraction (XPRD). MIG had a glass transition (T g) and melting peak of 90 and 318.795°C respectively. This material showed a 14.59 % loss in weight at 200°C. The sample had peaks at approximately 21°, 29°, and 39° 2 degrees of 2-theta(Ɵ) in the X-Ray Powder Diffraction pattern. Elemental analysis showed that MIG contains carbon-35.62, hydrogen-6.12, and oxygen-56.57 and nitrogen-1.67%. Paracetamol tablets were prepared by wet granulation technique using MIG as a tablet binder in the concentrations of 2.5, 5.0 & 7.5 % w/w, and compared with two standard binders.(2) The prepared tablets were evaluated for tablet characteristics. The evaluation of granules showed angle of repose ranges from 35.46-36.13°. The hardness of the prepared tablets varies from 9.5-15.5 kg/cm2. The prepared tablets showed 1.34-0.56 % friability, 5.75 min disintegration time and the in vitro drug release was more than 90% at 30 min. Tablets with 5% w/w binder concentration showed optimum results than two standard binders, thus conclusion was drawn that MIG was found to be useful for the preparation of uncoated tablet dosage form.