01-12-2012, 01:20 PM
TRANSDERMAL PATCHES: A SYNERGISTIC APPROACH OF DRUG DELIVERY FOR NSAIDs
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ABSTRACT
Transdermal drug delivery system has been accepted as potential non-invasive route of drug administration, with advantages of prolonged therapeutic effect, reduced side effects, improved bioavailability, better patient compliance and easy termination of drug therapy. Non-steroidal anti-inflammatory drugs (NSAIDs) represents the most commonly used medications for the treatment of pain and inflammation, but numerous well-described side effects can limit their use. Therefore transdermal delivery of NSAIDs has advantages of avoiding hepatic first pass effect, gastric irritation and delivering the drug for extended period of time at a sustained level. The present article gives the brief view on the work been done on various NSAIDs by formulated and delivered as transdermal patches to decrease the side effects associated with the oral delivery. The various NSAIDs included in this article include Ketoprofen, Ibuprofen, Naproxen, Fluribrofen, Diclofenac, Aceclofenac, Ketorolac, Indomethacin, Meloxicam, Nimesulide, Celecoxib, Etoricoxib.
INTRODUCTION:
The skin has attracted much attention as an alternative route for administering systemically active drugs. The potential advantages associated with transdermal drug delivery are well documented 1. Transdermal therapeutic systems are defined as self contained, discrete dosage forms which, when applied to the intact skin, deliver the drug(s), through the skin, at controlled rate to the systemic circulation. Thus, it is anticipated that transdermal drug delivery system (TDDS) can be designed to maintain suitable plasma drug levels for therapeutic efficacy by using skin as the port of entry of drugs 2.
CONCLUSION:
Oral non steroidal ant-inflammatory drugs (NSAIDs) are effective pharmacotherapy for a wide variety of painful, inflammatory disorders. Development of an efficient means of transdermal administration of NSAIDs could increase local soft tissue and joint concentrations while reducing side effects associated with oral administration.
All NSAIDs cannot be given by this route because the drug should possess certain physicochemical properties which are prerequisite for the transdermal delivery of drugs. Thus, the potential of this delivery system need to be explored in case of NSAIDs.