18-08-2012, 11:19 AM
Controlled Drug Delivery System
ControlledDrugDeliverySystem.ppt (Size: 3.42 MB / Downloads: 683)
Ideal” Drug Delivery System
Inert
Biocompatible
Mechanically strong
Comfortable for the patient
Capable of achieving high drug loading
Readily processable
Safe from accidental release
Simple to administer and remove
Easy to fabricate and sterilize
Free of leachable impurities
Modified Drug Release
Release can be:
instantaneous (delayed-release)
zero-order process (sustained release - mostly non-oral)
first-order process (oral extended release)
Terminology
Sustained release:
any dosage form that provides medication over an extended time
timed release, prolonged release etc
Controlled release:
denotes that the system is able to provide some actual therapeutic control, whether this be of a temporal nature, spatial nature, or both
Traditional vs. Controlled Release
With traditional administration, the drug active must remain between a maximum blood level value which may represent a toxic level and a minimum value below which the drug is no longer effective
With controlled administration, the blood levels are constant between the desired maximum and minimum for an extended period of time