14-09-2012, 10:44 AM
Formulation and evaluation of oral disintegrating tablets of domperidone
Formulation and evaluation.pptx (Size: 356.37 KB / Downloads: 134)
INTRODUCTION
Oral disintegrating tablets:
A solid oral dosage form that disintegrates orally in the mouth.
OTD’s are also called as orodispersible tablets, quick disintegrating tablets, mouth dissolving tablets, porous tablets, rapimelts, etc.
Advantages:
Provide good stability, accurate dosing, easy manufacturing, small packaging size and easy to handle.
No risk of obstruction of dosage form.
Disadvantages:
ODT’s are hygroscopic in natures so must be stored in dry place.
It also shows the fragile and effervescence property.
Industrial Applications:
To further improvise upon the existing technology of ODT’s.
To optimize the blend of disintegrants or excipients to achieve ODT’s.
AIM AND OBJECTIVE
To formulate and evaluate domperidone oral disintegrating tablets by direct compression method.
To increase the solubility and dissolution rate of domperidone by using crospovidone and mannitol.
To achieve a better dissolution rate and further improving the bioavailability of the drug.
To formulate ODT with sufficient mechanical integrity and to achieve faster disintegration in the oral cavity without water.
SUMMARY AND CONCLUSION
In the present work, oral disintegrating tablets of DOMPERIDONE were designed with a view to enhance patient compliance, by direct compression. In the direct compression method, crospovidone was used as disintegrant. The prepared batches of tablets were evaluated for hardness, friability, drug content uniformity, wetting time, water absorption ratio, In vitro dispersion time.
Among the tablets prepared by direct compression method formulation F3 was found to be promising. This formulation was tested for in vitro drug release pattern (in 0.1N Hcl) which showed 100% drug release in 30 minutes and marketed product gave 101% in 30 minutes. The formulation F3 has shown better control over drug release of marketed product.