06-12-2012, 06:28 PM
SELF EMULSIFYING DRUG DELIVERY SYSTEMS (SEDDS) AS A NOVEL CONCEPT IN DRUG DELIVERY APPROACH : A REVIEW
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Abstract
Self Emulsifying Drug Delivery Systems (SEDDSs) are mixtures of oils and surfactants, ideally isotropic and sometimes containing cosolvents, which emulsify spontaneously to produce fine oil-in-water emulsions when introduced into an aqueous phase under gentle agitation. The formulation of a SEDDS depends upon the solubility of the drug in different oil, surfactants and
cosolvents. The self emulsifying process depends upon the nature of the oil-surfactant ratio, concentration of the surfactant and temperature at which self-emulsification occurs. SEDDSs present drugs in a small droplet size and well-proportioned distribution, and increase the dissolution and permeability. SEDDSs protect drugs against hydrolysis by enzymes in the GI tract and reduce the presystemic clearance in the GI mucosa and hepatic first-pass metabolism. The characterization of the SEDDSs can be achieved by visual assessment, turbidity measurement, droplet size, zeta potential measurement and determination of emulsification time.